Professor Kim Hyung-sik’s research team at Hanyang University, in collaboration with Harvard University, has developed a next-generation nano-immunotherapy platform called ‘MyTai(Myeloid Cell-Targeted Immunostimulant Cocktail).’ The research was published in the October 2025 issue of internationally renowned journal ACS Nano, with Professor Kim as the first author.

Professor Kim has been researching immune engineering based on drug delivery. Especially, he has been developing a carbohydrate-based nanoparticle platform that controls immune cells precisely in human bodies. MyTai delivers therapeutics such as RNA, immune-activating small molecules, and proteins specifically to immune cells. This approach triggers effective immune responses not only in traditionally hard-to-treat ‘cold tumors’ but also in autoimmune and rare diseases.

Professor Kim’s research team began this study to address the limitations of existing cancer immunotherapies. Existing therapies do not work effectively in tumor environments where immune cells do not function properly.

The ‘tumor environment’ is a complex ecosystem created by the entanglement of blood vessels, immune cells, fibroblasts, nutrients, and signaling molecules surrounding cancer cells. Cancer cells grow by shaping this environment to their own advantage. As a result, the environment becomes suppressive so that immune cells lose their function, and even powerful drugs cannot reach the target cells. Professor Kim felt the need for a ‘new way of training immune cells directly’ as existing methods have limited treatment efficiency and began research on immune-cell-targeted nano-carriers to realize the training process.

실시간 해와 토토사이트 is a multi-immunomodulatory therapeutic system that precisely stimulates myeloid immune cells such as dendritic cells and macrophages. Myeloid immune cells are key cells that command and coordinate immune responses: if lymphoid cells(T and B cells) carry out attacks, myeloid cells are the commanders who design the strategies of the immune network. 실시간 해와 토토사이트 is a technology to fundamentally restructure the immune system by retraining these commander cells.

MyTai is designed to simultaneously stimulate the TLR3, TLR7/8, and NF-kB pathways within a single nanoparticle. These three pathways are core signal switches that enable myeloid cells to recognize external stimuli and initiate a response. TLRs(Toll-Like Receptors) are immune sensors that send a signal that ‘an enemy has entered’ when bacteria or viruses invade. At this time, TLR3 recognizes viral RNA, and TLR7/8 recognizes foreign RNA inside the cell. When these pathways are activated, immune cells react as if a virus invades and initiate the defense system.

NF-kB is an internal signaling circuit that, after such alarms, spreads the immune response throughout the whole body. When this circuit is turned on, cells begin full-scale immune activity by massively producing cytokines(immune proteins). 실시간 해와 토토사이트 simultaneously stimulates these signaling systems, strongly activates myeloid immune cells, and converts them into a trained state. In this way, 실시간 해와 토토사이트 induces a stronger and more sustained anti-cancer immune response than existing single immunostimulants.

Whereas conventional immuno-cancer treatments mainly focused on activation of T cells, 실시간 해와 토토사이트 directly regulates the commander cells of immunity, antigen-presenting cells(APCs). The typical APCs are the myeloid cells mentioned above, namely dendritic cells and macrophages.

실시간 해와 토토사이트 not only switches on immune responses but also reprograms the internal signaling and gene expression system of antigen-presenting cells so that the tumor environment is exposed to the immune system.

Immune cells that have been exposed to the tumor environment for a long time gradually turn into a tolerant state, losing their abilities to recognize or attack external antigens. 실시간 해와 토토사이트 reactivates the signal transduction and gene expression of these cells, restoring their original attack function. In other words, 실시간 해와 토토사이트 is a cell re-education system that returns immune cells to a trained state, enabling them to precisely recognize antigens and lead the immune response.

실시간 해와 토토사이트 uses a carbohydrate-based structure with high biocompatibility. Upon repeated administration to experimental animals, no inflammation or toxic reactions were observed in major organs such as the liver, spleen, or kidneys, and blood enzyme levels(AST, ALT, and more) remained within normal ranges. Its stability is also evaluated as a major strength in the preclinical stage.

Furthermore, MyTai shows high potential for extensions to vaccines for infectious diseases and treatments for autoimmune diseases. Currently, GLP toxicity evaluation, preclinical efficacy validation, and mass production process optimization are underway, and collaborative research with both domestic and international pharmaceutical companies is being pursued. Professor Kim stated, “Our long-term goal is to develop this into a customized immunotherapy platform tailored to each patient’s immune characteristics.”

Professor Kim continues research to develop next-generation mRNA vaccines and immunotherapeutic nanovaccines based on his own nanoimmunology platform. In particular, he is designing a vaccine system that induces 실시간 해와 토토사이트 cells to effectively recognize and remember antigens in the tumor environment.

The goal is to form tertiary lymphoid structures around tumors, strengthen immune memory, and realize therapeutic vaccines that suppress recurrence in the long term. Professor Kim said, “Ultimately, I want to expand this to a universal immune-control vaccine platform that can be applied not only to cancer but also to infectious and autoimmune diseases.”

At the end of the interview, Professor Kim left a final message for Hanyang students who are trying to study biomedical science:
"Biomedical science is a convergent discipline that requires both understanding of life and engineering creativity. I think the essence of research is not about knowing the right answer, but about asking questions and exploring them on your own. I hope Hanyang students will be filled with the passion to become researchers who change the world, and together we can create a research culture unafraid of failure."